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On the other hand, ROS induce the binding of Src homology 2 domain-containing phosphatase 1 (SHP1) to c-Src and the oxidation of c-Src and SHP-1, which lead to SHP-1 inactivation and activation of c-Src via phosphorylation of Tyr416, contributing to osteoclast survival and increasing bone loss (226)

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Yuan, Y., Andersen, E

92 In contrast to COPD, the Wnt/-catenin pathway is activated in the lung epithelium of IPF

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